Plasmid DNA

Plasmid DNA

Ultra-fast and easy to use kits for the isolation of plasmid DNA at Miniprep, Midiprep, Maxiprep, and up to Gigaprep scale. High-quality plasmid DNA purification kits lead to extremely reliable downstream applications. Read more.
PLASMID DNA PURIFICATION GUIDE. Tailored technologies of pure plasmid DNA.

NucleoBond® Xtra MIDI & MAXI
Transfection-grade plasmid DNA with anion exchange technology.

NucleoBond® Xtra MIDI & MAXI EF
Endotoxin-free plasmid DNA with Patented endotoxin removal!

NucleoSpin® Plasmid/Plasmid Transfection Grade/Plasmid Easy Pure
For rapid small scale preparation of high-purity plasmid DNA.


Genomic DNA

Genomic DNA

DNA Purification and amplification kits from Macherey-Nagel.

Isolate DNA the easy and efficient way - optimal lysis efficiency for various sample materials. DNA GUIDE.

Short preparation times with best results. New solutions for Direct PCR. Read more.



NucleoSpin® Tissue. Allround kits for purification of DNA from a broad range of samples.
NucleoSpin® Tissue XS.

NucleoSpin® DNA RapidLyse. For rapid extraction of total DNA from tissue and organs. Powerful lysis!

NucleoSpin® DNA Lipid Tissue. Isolation of DNA from lipid rich tissue


NucleoSpin® Plant II. Rapid isolation of DNA from a multitude of plant samples

NucleoSpin® DNA Insect. Isolation of DNA from insects, crustaceans, and arachnids

NucleoSpin® DNA Yeast. NEW! Isolation of total DNA from yeast and fungi


NucleoSpin® Blood. For rapid purification of high quality DNA from blood in single to high throughput format
NucleoSpin® Blood XL.
NucleoSpin® Blood L.

NucleoSpin® cfDNA XS. Micro kit for cell-free DNA from plasma.

NucleoSpin® DNA FFPE XS. DNA recovery from formalin-fixed, paraffin-embedded samples. Patented technology.


NucleoSpin® Microbial DNA. For purification of high-quality DNA from gram-positive and gram-negative bacteria, yeast, and fungi

NucleoSpin® DNA Stool. Isolation of DNA from stool samples


NucleoSpin® Food. For rapid isolation of DNA from food and feed

NucleoSpin® eDNA Water. NEW! Isolation of environmental DNA (eDNA) from water samples.

NucleoSpin® Soil. Isolation of total DNA from diverse soil types



MN Bead Tubes Improve Lysis Efficiency. Genomic RNA/DNA from HARD TO LYSE samples.

MN Bead Tube Overview. Different types (A-G). Compatible with common disruption devIces. Beads in bulk also available. Read more.

MN hard to lyse MN bead tube holder




RNA Purification

Tailored solutions for high-grade RNA extractions from MACHEREY-NAGEL.

For diverse samples and applications with flexible formats and technologies.

RNA Purification guide.


 RNA from cells and tissue

NucleoSpin® RNA. RNA isolation kits from very small to large scale. High quality RNA from diverse sample materials. Choose the format you need - from XS to Midi prep.
NucleoSpin® RNA XS
NucleoSpin® RNA Midi

NucleoSpin® RNA Plus.Ultrafast and convenient RNA isolation.DNA removal without enzymatic digestion.
NucleoSpin® RNA Plus XS

NucleoZOL.The universal RNA isolation reagent. No chloroform, no phase separation.

NucleoProtect® RNA. NEW! RNA stabilization reagent for cells and tissues.

MicroRNA from cells, tissue and plasma

NucleoSpin® miRNA. Isolation of small RNA, large RNA and proteins. Isolate total RNA including miRNA.

NucleoSpin® miRNA Plasma. Isolation of small RNA, DNA from plasma, serum and exosomes.


RNA Clean up
NucleoSpin® RNA Clean-up XS. Mini and Micro kit from RNA clean-up.
NucleoSpin® RNA Clean-up


RNA, DNA and protein

NucleoSpin® RNA/Protein. Parallel isolation of RNA and proteins.

NucleoSpin® TriPrep. Parallel isolation of RNA, DNA and proteins.

NucleoSpin® RNA/DNA Buffer Set. Buffer set for parallel isolation of RNA and DNA with NucleoSpin® RNA kits.



DNA and RNA Clean up

Get the best templates for your downstream applications. DNA AND RNA CLEAN UP GUIDE.

NucleoSpin®Gel and PCR Clean-up
PCR clean up and gel extraction – the two in one kit.

NEW! NucleoSpin® Gel and PCR Clean-up XS. Concentrated clean up with small elution volumes

NucleoSpin® RNA Clean-up & RNA Clean-up XS. Mini kit for RNA clean up and concentration

NucleoSpin® Inhibitor Removal. Get pure and amplifiable DNA for your downstream application!

NucleoMag® NGS Clean-up and Size Select. Magnetic-bead based clean-up and size selection of NGS library preparation reactions. NEW! Now also for RNA Clean-up.

NucleoSpin® gDNA Clean-up. Mini kit for effective post clean up and concentration of genomic DNA.

NucleoSpin® gDNA Clean-up XS. Micro kit for effective post clean up and concentration of genomic DNA.



Entsymatic clean-up of PCR products. Product flyer - read more.

Viral RNA and DNA Purification kits

Viral RNA and DNA

RNA and DNA isolation kits have been optimized for use with cell‑free biological fluids and diverse veterinary and clinical samples. They are specialized for low viral titers and large sample volumes and are characterized by highest consistency and sensitivity for different types of viruses. Read more 


Viral RNA / DNA from serum and plasma.

NucleoSpin® RNA Virus. Mini kit for viral RNA/DNA from cell-free fluids.

NucleoSpin® Virus. Mini spin kit for time saving parallel isolation of viral RNA / DNA from different samples.

NucleoSpin® Dx Virus. Mini kit for CE certified purification of viral RNA/DNA.

NucleoMag® Virus. Magnetic bead based isolation of viral RNA and DNA from cell-free biological fluids.

NucleoSpin® 96 Virus. Time saving parallel isolation of viral RNA / DNA from biological fluids in proven 96‑well plate format.


Viral RNA /DNA and bacterial DNA from clinical samples

NEW! NucleoMag® Dx Pathogen (CE-IVD). CE-IVD-certified for viral RNA isolation from respiratory samples has been validated for SARS-CoV-2 diagnostic workflows.

NucleoMag® Pathogen. Magnetic bead based isolation of viral RNA/DNA and bacterial DNA.


Viral RNA / DNA and bacterial DNA from veterinary samples

NucleoMag® VET


Viral DNA from blood

NucleoSpin® Blood



High Throughput HTP

HTP          NucleoMag kits


MACHEREY-NAGEL offers a variety of kits for high throughput (HTP) nucleic acid and protein purification. Kits for all applications are available for both manual and automated use on common laboratory robotic platforms. Read more.

NucleoMag® Kits
For rapid manual and automated preparation of highly pure nucleic acids. The NucleoMag® kits allow an easy automation on common liquid handling instruments.
NucleoSpin® 96 Kits
Purification of multiples of 96 samples. The kits are supplied with accessory plates for highest convenience and are designed for manual or automated use in a centrifuge or for use with a vacuum manifold.

Automation partners and application notes:
MACHEREY‑NAGEL supply validated scripts on request. The specialists from R&D assist you to generate customized scripts for different robotic platforms if needed. MN experts help you to optimize or adjust your scripts on request e.g., to process new sample material.
Application notes. MN offers a broad range of application notes. These application notes contain detailed descriptions on how to use low, medium, and high throughput kits from MN on different robotic platforms.
Available application notes and scripts of automation partners: Eppendorf, Hamilton, Tecan,Thermo Scientific (KingFisher) and Andrew Alliance.

MACHEREY-NAGEL High Throughput Processing Guide. Read here.


APPLICATION NucleoMag® KIT NucleoSpin® 96 KIT
Plasmid DNA   NucleoSpin® 96 Plasmid
PCR clean-up NucleoMag® 96 PCR NucleoSpin® 96 PCR Clean-up
NGS clean-up and size selection NucleoMag® NGS Clean-up and Size Select  
RNA from cells and tissue NucleoMag® RNA NucleoSpin® 96 RNA
DNA from blood NucleoMag® Blood 3 ml NucleoSpin® 96 Blood
NucleoMag® Blood 200 ul NucleoSpin® 96 Blood QuickPure
Cell-free DNA from plasma NucleoMag® cfDNA NucleoSpin® 96 cfDNA
DNA from tissue and cells NucleoMag® Tissue NucleoSpin® 96 Tissue
NucleoSpin® 96 RapidLyse
DNA from FFPE samples NucleoMag® DNA FFPE NucleoSpin® 96 DNA FFPE
DNA from bacteria and yeast NucleoMag® DNA Bacteria  
DNA from microbiome NucleoMag® DNA Microbiome  
DNA from Stool   NucleoSpin® 96 Stool
DNA from diverse soil types   NucleoSpin® 96 Soil
DNA from forensic samples NucleoMag® DNA Forensic NucleoSpin® 96 Trace
DNA from plant and fungi NucleoMag® Plant NucleoSpin® 96 Plant
NucleoMag® 384 Plant
DNA from food and feed NucleoMag® DNA Food NucleoSpin® 96 Food
Viral RNA and DNA NucleoMag®  Virus NucleoSpin® 96 Virus
Viral RNA/DNA and bacterial DNA NucleoMag® Dx Pathogen  
NucleoMag® VET  
Environmental RNA/DNA NEW! NucleoMag® RNA/DNA Water  
DNA Swab NucleoMag DNA Swab  


Buffers, Enzymes and accessories




  • Proteinase K, 100 mg: Proteinase K and Proteinase Buffer PB
  • RNase A, 100 mg
  • rDNase Set: Highly specific recombinant DNase for efficient removal of contaminating DNA.


NucleoSpin® Bead Tubes: MN solution for RNA or DNA purification from hard to lyse sample materials.